MRFF Research grant – 2020 MRFF Traumatic Brain Injury Mission

Grant Duration: 3 years

Administering Institution: The University of Queensland

Traumatic brain injury (TBI) has considerable impact on patients, families, and the community as a whole because patients show substantial variation in injury mechanisms, pathology and clinical severity. As a result, prognosis of functional outcome after TBI is challenging, although it is very important in providing reliable information for guiding patient management.

The prognostic models currently available rely on simplistic information that questions their usefulness in clinical practice. We propose the PREDICT-TBI trial, a multicentre study that will collect a comprehensive suite of novel blood-based biomarkers, clinical information, cognitive data, and advanced magnetic resonance imaging (MRI) from 300 patients with moderate-to-severe TBI.

An innovative data-driven approach is constructed via state-of-the-art artificial intelligence models that will decipher those components most relevant to informing patient outcomes.

The purpose of the PREDICT-TBI study is to develop a prognostic model by using a multimodal approach of different prognostic indicators and their evolution over time within the first 6 months post-injury. The added benefit of MRI to this prognostication will also be explored. The results of this study will provide objective information that will facilitate the shared decision-making process with patients and families.