Nonpharmacological treatment of Persistent Postconcussion Symptoms in adults: A systematic review and meta-analysis and guideline recommendation

Key Points of this Research Article

Research Question What is the evidence for nonpharmacological interventions to treat persistent postconcussion symptoms (PPCS)?

Findings Following a systematic review and meta-analysis of 19 randomized clinical trials comprising 2007 participants, using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) method, weak recommendations were assigned for the following nonpharmacological treatments for PPCS:
– systematic provision of early information and advice,
– use of graded physical exercise,
– vestibular rehabilitation,
– psychological treatment, and
– interdisciplinary rehabilitation.
No studies were identified regarding oculomotor vision treatment, resulting in a consensus-based statement.

Meaning Based on very low to low certainty of evidence or on consensus, individually tailored nonpharmacological treatment of persistent symptoms was recommended, both through specific disciplines and interdisciplinary rehabilitation.