An informatics approach to predict outcomes and monitor intervention efficacy following moderate to severe TBI

MRFF research grant – 2020 Traumatic Brain Injury Mission

Grant Duration: 2 years

Administering University: Curtin University

This project will provide the mechanism to revolutionise personalised care and treatment for people who experience traumatic brain injury (TBI). We will comprehensively address the key knowledge gap, by designing an approach to bring together data describing psychosocial modulators, clinical measures, imaging and fluid biomarkers, and rehabilitation outcomes, in a meaningful way.

Data management systems will be designed to track a broad range of suitable indicators and outcomes, organised to facilitate secure data collection, linkage, storage, management and analysis. These bold objectives are achievable because of the substantial commitments by our consortium of national and international leaders, Expert Committees and partner organisations in TBI and health informatics. This project will be fundamental to the success of the Mission for TBI and will lead to substantial breakthroughs.

In Aim 1, we will determine the most useful common data elements that can be feasibly and reliably collected from all Australians who experience TBIs. We will utilise an evidence-based, consensus approach to identify suitable indicators and outcomes useful for predicting outcomes and tracking efficacy of interventions.

The data we will collect will cover the entire trajectory of people’s journeys, from injury to integration back into community; include people from all states and territories in Australia and encompass all demographics; and span the diversity of presentations of people with moderate to severe TBI, including those with multiple injuries and co-morbidities.

In Aim 2, we will design an informatics approach to optimally collect, link, store, manage and protect the data, thereby facilitating researcher access to a world-leading nationally consistent, high-quality linked dataset. The resultant data will stimulate research to develop more effective evidence-based care for TBI through improved care pathways and decision-making for moderate to severe TBI.